HER-family gene amplification and expression in resected pancreatic cancer
EA Te Velde, AC Franke, R Van Hillegersberg… - European Journal of …, 2009 - Elsevier
AIMS: Despite surgical resection, pancreatic cancer carries a poor prognosis. In search for
new molecular therapeutic targets, we investigated the expression of the HER-family and
gene amplification of HER-2 in pancreatic adenocarcinomas of different stages. METHODS:
Tissue of 45 resected patients was analyzed for all HER-family 1-4 expression by
immunohistochemistry and HER-2 gene amplification was assessed by multiplex ligation-
dependent probe amplification and chromogenic in situ hybridization. The type of surgery …
new molecular therapeutic targets, we investigated the expression of the HER-family and
gene amplification of HER-2 in pancreatic adenocarcinomas of different stages. METHODS:
Tissue of 45 resected patients was analyzed for all HER-family 1-4 expression by
immunohistochemistry and HER-2 gene amplification was assessed by multiplex ligation-
dependent probe amplification and chromogenic in situ hybridization. The type of surgery …
