[HTML][HTML] Tumor necrosis factor α-mediated induction of interleukin 17C in human keratinocytes is controlled by nuclear factor κB
C Johansen, JL Riis, A Gedebjerg, K Kragballe… - Journal of Biological …, 2011 - ASBMB
IL-17C is a member of the IL-17 family of cytokines. The expression of IL-17C has been
demonstrated to be strongly induced by TNFα in human keratinocytes, and recently the level
of IL-17C was found to be increased in the inflammatory skin disease psoriasis. However,
little is known about the molecular mechanisms involved in the regulation of IL-17C. Here,
we show that pretreatment of cultured human keratinocytes with the inhibitor of κB kinase 2
inhibitor, SC-514, resulted in a significant reduction in both IL-17C mRNA and protein …
demonstrated to be strongly induced by TNFα in human keratinocytes, and recently the level
of IL-17C was found to be increased in the inflammatory skin disease psoriasis. However,
little is known about the molecular mechanisms involved in the regulation of IL-17C. Here,
we show that pretreatment of cultured human keratinocytes with the inhibitor of κB kinase 2
inhibitor, SC-514, resulted in a significant reduction in both IL-17C mRNA and protein …
